Last edited by Nikogami
Friday, May 15, 2020 | History

8 edition of Neuropilin found in the catalog.

Neuropilin

From Nervous System to Vascular and Tumor Biology (Advances in Experimental Medicine and Biology)

by Dominique Bagnard

  • 255 Want to read
  • 16 Currently reading

Published by Springer .
Written in English

    Subjects:
  • Neurology & clinical neurophysiology,
  • Neurosciences,
  • Neurology (General),
  • Vascular Disease,
  • Medical,
  • Medical / Nursing,
  • Biochemistry,
  • Life Sciences - Biochemistry,
  • Neuroscience,
  • Medical / Neurology,
  • Medical / Neuroscience,
  • Cardiology,
  • Neurology - General,
  • Nerve Tissue Proteins,
  • Neuropilins,
  • Receptor, Epidermal Growth Fac,
  • Receptor, Epidermal Growth Factor,
  • Vascular Cell Adhesion Molecul,
  • chemistry

  • The Physical Object
    FormatHardcover
    Number of Pages140
    ID Numbers
    Open LibraryOL10325060M
    ISBN 100306474166
    ISBN 109780306474163

    This book covers basic research topics such as the structure-function relationships of neuropilins and mechanisms of neuropilin-mediated signal transduction, details the most important roles of the neuropilins in developmental biology, and addresses their roles in various conditions such as cancer. Fujita H, Zhang B, Sato K et al. Expressions of neuropilin-1, neuropilin-2 and semaphorin 3A mRNA in the rat brain after middle cerebral artery occlusion. Brain Cited by:

    Neuropilin ‐1 is present in Open book preparation of chick hindbrain at stage 15 showing Sema 3F expression throughout the dorsal–ventral axis of r1, r3, and Cited by: Any of a group of glycoproteins which act as transmembrane receptors in neurons.

    Semaphorins are secreted and transmembrane proteins that bind plexin/neuropilin or integrin receptors, providing paracrine axonal guidance signals and ultimately leading to a functional and developed neuronal network. Following semaphorin’s initial discovery, their relevance in the central nervous system (CNS) soon intrigued researchers about the possible links between semaphorins, their Author: Maria Valenzuela, Sebastian Quintremil, Fernando Medina Ferrer, Maria Elsa Pando, Javier Puente. Neuropilin-1 (NRP1) is a transmembrane receptor playing a pivotal role in the control of semaphorins and VEGF signaling pathways. The exact mechanism controlling semaphorin receptor complex formation is .


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Neuropilin by Dominique Bagnard Download PDF EPUB FB2

Neuropilin Neuropilin book a protein receptor active in neurons. There Neuropilin book two forms of Neuropilins, NRP-1 and NRPThey are transmembrane glycoproteins, and predominantly co-receptors for another class of proteins known as vega-books.com the semaphorins, NRP-1 and NRP-2 are specifically receptors for class-3 semaphorins, which, among many things, are responsible for axon guidance during the development InterPro: IPR A Neuropilin book family is composed of neuropilin-1 and several splice variants of neuropilin-2 [1].

Neuropilin-1 and -2 contain a number of conserved motifs on their extracellular domain, including two CUB domains, FV/FVIII, and a MAM domain. The CUB domains are required for ligand binding, and the MAM domain mediates neuropilin oligomerization [10].

Neuropilin 2 (NRP2) is a protein that in humans is encoded by the NRP2 gene. This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted Aliases: NRP2, NP2, NPN2, PRO.

Buy Neuropilin: From Nervous System to Vascular and Tumor Biology (Advances in Experimental Medicine and Biology Book ): Read Books Reviews - vega-books.comce: $ Apr 27,  · Read "Neuropilin From Nervous System to Vascular and Tumor Biology" by available from Rakuten Kobo.

Cell adhesion is one of the most important properties controlling embryonic development. Extremely precise cell-cell con Brand: Springer US. Ten years later, two groups discovered that neuropilin is a receptor for guidance signals of the semaphorin family.

Axon guidance is a critical step during brain development and the mechanisms ensuring growth cone navigation are beginning to be well understood. Neuropilin: From Nervous System to Vascular and Tumor Biology (Advances in Experimental Medicine and Biology) [Dominique Bagnard] on vega-books.com *FREE* shipping on qualifying offers.

Cell adhesion is one of the most important properties controlling embryonic development. Extremely precise cell-cell contacts are established according to the nature of adhesion molecules that are expressed on the Author: Dominique Bagnard.

Neuropilin Expression in Endothelial Cells. There have been a number of reports demonstrating that blood vessel EC express NRPs; for example, umbilical vein EC, aortic EC and capillary EC.

12,48 Expression in vivo has been demonstrated, for example, in the heart, 11 coronary blood vessels, 49 glomerular capillaries, 50 and bone capillaries. 17,18 Vascular smooth muscle cells (vSMC) also Cited by: Injury to the mature mammalian central nervous system (CNS) is often accompanied by permanent loss of function of the damaged neural circuits.

The failure of injured CNS axons to regenerate is thought to be caused, in part, by neurite outgrowth inhibitory factors expressed in and around the lesion. These include several myelin-associated inhibitors, proteoglycans, and vega-books.com by: Get this from a library. Neuropilin: from nervous system to vascular and tumor biology.

[Dominique Bagnard;] -- This comprehensive book is designed to illustrate the diverse functions of this basic adhesion molecule. It presents the discovery of neuropilin and demonstrates its pricipal functions in the.

Jul 16,  · Do you want to remove all your recent searches. All recent searches will be deleted. This book covers basic research topics such as the structure-function relationships of neuropilins and mechanisms of neuropilin-mediated signal transduction, details the most important roles of the neuropilins in developmental biology, and addresses their roles in.

Get this from a library. Neuropilin: From Nervous System to Vascular and Tumor Biology. [Dominique Bagnard] -- This volume provides an analysis on how a single molecule is able to encode a wide range of functions in various biological systems, contributing to the disappearance of frontiers in biology.

Independent groups t test was used to analyze the immunostain intensity scores with a P Cited by: 7. Neuropilin-1 is a kDa transmembrane protein that binds CLASS 3 SEMAPHORINS, and several other growth factors.

Neuropilin-1 forms complexes with plexins or VEGF RECEPTORS, and binding affinity and specificity are determined by the composition of the neuropilin dimer and the identity of other receptors complexed with it. The ALK1 (ALK1 cline) antibody labels normal human ALK protein and the NPM-ALK chimeric protein, and is a useful tool for the identification of the subgroup.

We report the molecular design and synthesis of EG, 2, the first small molecule ligand for the VEGF-A receptor neuropilin 1 (NRP1) and the structural characterization of NRP1−ligand complexes by NMR spectroscopy and X-ray crystallography.

Mutagenesis studies localized VEGF-A binding in the NRP1 b1 domain and a peptide fragment of VEGF-A was shown to bind at the same site by NMR. Neuropilin-1 (NP1), in conjunction with plexins, promotes axon repulsion by binding to semaphorin 3A (SEMA3A). Although NP1 is expressed in carcinoma cells, its functions have remained elusive, and neither SEMA3A nor plexin expression has been explored in cancer.

Here we provide evidence that breast carcinoma cells support an autocrine pathway involving SEMA3A, plexin-A1, and NP1 that Cited by: from book Biomarkers of the Tumor Microenvironment: Neuropilin 1 is highly expressed in PDACs, and high expression of NRP-1 is significantly correlated with angiogenesis, advanced tumor-node.

Jun 12,  · Breast cancer is the second most common cause of cancer-related deaths in females, with an estimated 41, deaths in the USA in Although, the 5 Cited by: 6. In the immune system, Neuropilin-1 (Nrp1) is a molecule that plays an important role in establishing the immunological synapse between dendritic cells (DCs) and T cells.The role of vascular endothelial growth factor (VEGF) signaling in cancer is not only well known in the context of angiogenesis but also important in the functional regulation of tumor cells.

Autocrine VEGF signaling mediated by its co-receptors called neuropilins (NRPs) appears to be essential for sustaining the proliferation and survival of cancer stem cells (CSCs), which are implicated in Cited by: We have designed a novel peptide–docetaxel conjugate, which delivers docetaxel specifically to cancer cell targeting neuropilin-1 (NRP-1) receptor, thus enhancing its efficacy and acts more aggressively in breast cancer cells.